Alzheimer Research Series on the Default Network
نویسندگان
چکیده
منابع مشابه
Alzheimer research series on the default network.
The idea of the default mode network, an interconnected set of brain regions that are active when the brain is resting and that power down during focused mental tasks, was first proposed in 2001, but it quickly became a hot topic in cognitive neuroscience and for Alzheimer’s disease (AD) researchers. The seesaw activation and deactivation of the default network and task-related brain regions ap...
متن کاملImpaired default network functional connectivity in autosomal dominant Alzheimer disease.
OBJECTIVE To investigate default mode network (DMN) functional connectivity MRI (fcMRI) in a large cross-sectional cohort of subjects from families harboring pathogenic presenilin-1 (PSEN1), presenilin-2 (PSEN2), and amyloid precursor protein (APP) mutations participating in the Dominantly Inherited Alzheimer Network. METHODS Eighty-three mutation carriers and 37 asymptomatic noncarriers from...
متن کاملDeveloping an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network.
The Dominantly Inherited Alzheimer Network (DIAN) is a collaborative effort of international Alzheimer disease (AD) centers that are conducting a multifaceted prospective biomarker study in individuals at-risk for autosomal dominant AD (ADAD). DIAN collects comprehensive information and tissue in accordance with standard protocols from asymptomatic and symptomatic ADAD mutation carriers and the...
متن کاملMultimodal Imaging of Alzheimer Pathophysiology in the Brain's Default Mode Network
The spatial correlations between the brain's default mode network (DMN) and the brain regions known to develop pathophysiology in Alzheimer's disease (AD) have recently attracted much attention. In this paper, we compare results of different functional and structural imaging modalities, including MRI and PET, and highlight different patterns of anomalies observed within the DMN. Multitracer PET...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2010
ISSN: 1875-8908,1387-2877
DOI: 10.3233/jad-2010-1277